Medication to Increase Sperm Count

One of the biggest issues men face when trying to conceive a child is a low sperm count. While lifestyle changes can help improve fertility, such as reducing stress, exercising regularly, and eating a healthy diet, some men may need additional help to increase their sperm count. Medications are available that have been proven effective in improving male fertility by increasing the quantity and quality of sperm. They work by stimulating the body’s production of sperm and raising testosterone levels, thereby improving fertility.

In this article, we’ll discuss the various medications available to increase sperm count. We’ll explain how they work, their side effects, and when it’s best to use them for maximum benefit.

What this article covers:

Testosterone Replacement Therapy (TRT)

Testosterone replacement therapy is one of the most common treatments for men who need to increase sperm count. TRT involves injecting testosterone into the body either through intramuscular injections, patches, gels, or implants. It works by stimulating androgen receptors in the testes to produce more sperm.

When testosterone is injected into your body, it binds to certain receptors in the testes and stimulates them. This results in increased spermatogenesis (sperm production) and increased sperm motility (movement of sperm). The increased testosterone levels will also improve libido and sexual performance.

Once the desired level of testosterone is achieved, the patient will be monitored and the dosage may need to be adjusted to maintain the optimal levels of testosterone to increase sperm count.

TRT has been shown to increase sperm count significantly in many men. However, it’s important to remember that results can vary from person to person, and a consultation with your doctor should take place before making any decisions to pursue this type of treatment.

While it’s considered a safe and effective treatment, it’s important to understand the potential risks associated with TRT before making a decision. For example, long-term use can lead to an increased risk of prostate cancer and other hormonal imbalances. In addition, there have been reports of fertility issues in men who have used testosterone replacement therapy. Therefore, it’s essential to discuss all of the risks with your doctor before starting TRT.

Clomiphene Citrate (Clomid)

Clomiphene is an oral medication that’s used to stimulate ovulation in women, but it’s also been effective in men trying to increase sperm count. Clomiphene works by blocking the action of estrogen on the hypothalamus, which helps stimulate testosterone production and sperm production in men.

This medication also stimulates the pituitary gland to produce more luteinizing hormone (LH), increasing testosterone production. This results in increased spermatogenesis and improved sperm motility. 

It’s worth noting that only low dosages of Clomiphene are needed to improve sperm count; however, consultation with a doctor is necessary before taking this medication.

The most common side effect of clomiphene is hot flashes, but other possible adverse effects include headaches, visual disturbances (blurred vision or double vision), and mood changes.


HCG (Human Chorionic Gonadotropin) and HMG (Human Menopausal Gonadotropin) are medications that can also increase sperm count. HCG is usually prescribed for men with hypogonadotropic hypogonadism, a condition in which the body doesn’t produce enough of the hormones that control reproduction. It works by stimulating the testes to produce more testosterone and sperm.

HMG is prescribed for men who have a malfunctioning pituitary gland, which can cause a low sperm count. It works by triggering the pituitary gland to secrete luteinizing hormone and follicle-stimulating hormone, hormones that are required to stimulate the testicles to produce sperm. Both HCG and HMG are administered through injections, usually daily or weekly. Their effectiveness depends on the individual’s condition and response to treatment.

The side effects of these medications may include mild to moderate pain, swelling, tenderness, and redness at the injection site. Other potential side effects include acne, mood swings, headaches, and nausea. It is important to discuss any side effects with your doctor as soon as possible.

Anastrazole (Arimidex)

Anastrazole (Arimidex) is an aromatase inhibitor that has been used to increase sperm count in some men. Aromatase inhibitors work by blocking the action of the enzyme aromatase, which converts testosterone into estradiol, a form of estrogen. By reducing the amount of estradiol in the body, aromatase inhibitors can help increase testosterone production, leading to improved sperm count.

This medication was initially made for breast cancer but has also been effective in treating low sperm count. It contains the active ingredient anastrozole, which is available in both pill and injectable form. The dosage depends on the patient’s condition and the doctor’s recommendation.

The side effects associated with Anastrazole are relatively mild and include hot flashes, nausea, headaches, joint pain, and fatigue. It’s important to note that this medication can also interact with certain other drugs, so it’s important to discuss any medications or supplements for semen you’re taking with your doctor before starting Anastrazole.

Letrozole (Femara)

Letrozole (Femara) is a medication that’s sometimes used to increase sperm count in men. It belongs to a class of drugs known as aromatase inhibitors, which work by blocking the production of estrogen (the female hormone). This reduces the estrogen level in the body, increasing testosterone levels and thus increasing sperm production. Letrozole has been shown to be effective in increasing sperm count in some men, but it’s not a guaranteed treatment.

The way Letrozole works is that it reduces the amount of aromatase, an enzyme that converts testosterone into estrogen. By reducing the amount of aromatase, there’s less conversion of testosterone to estrogen, which allows for higher levels of testosterone in the body. Higher levels of testosterone can lead to increased sperm production and, thus, a higher sperm count.

When considering taking Letrozole, consult a doctor about potential risks and side effects. Possible side effects include nausea, vomiting, headaches, hot flashes, joint pain and fatigue. Additionally, the long-term use of Letrozole has been linked to osteoporosis (bone loss) and an increased risk of heart disease.


Bromocriptine (Parlodel) is another medication that’s been used to increase sperm count. This drug works by blocking the action of prolactin, a hormone that can inhibit testosterone production and lead to decreased sperm production.

Prolactin is a hormone that’s naturally produced by the pituitary gland, and it has several different functions in the body. One of these is its role in regulating sperm production. It works to inhibit testosterone production, which can lead to low sperm count if levels are too high.

Taking bromocriptine blocks the action of prolactin, allowing testosterone production to resume and sperm count to increase.

This medication also works to reduce the impact of stress on fertility. Stress can cause a decrease in hormones, including testosterone, which can lead to reduced sperm production. This is because stress can cause the body to release more cortisol, negatively affecting fertility.

Bromocriptine also helps to normalize hormone levels, especially testosterone and prolactin. This should help to treat any underlying issues that may be causing reduced sperm count, such as hypogonadism (low testosterone), hyperprolactinemia (high prolactin), or pituitary adenoma (noncancerous tumor).

To enhance the effectiveness of the drug, your doctor might advise you to use it alongside other methods, such as eating foods that increase sperm count or drinking juice to increase sperm count. These methods help to boost the effects of bromocriptine, making it more effective in increasing sperm count.

It’s important to note that, like any medication, there can be side effects associated with taking bromocriptine. Common side effects include nausea and vomiting, headaches, dizziness, vision changes, and weight loss. If you experience any of these side effects, you should contact your doctor immediately.


Imipramine, a tricyclic antidepressant (TCA), has been used for decades to treat depression and other conditions such as obsessive-compulsive disorder and panic attacks. It also has positive effects on sexual health, including increasing sperm count.

This medication works by increasing blood flow to the testicles and allowing them to produce more sperm.

Certain conditions can cause blood vessels to constrict, leading to decreased blood flow in the testicles. They include varicocele and stress.

Varicocele is a condition in which the veins around the testicles become enlarged and twisted, resulting in decreased blood flow.

Imipramine is an antidepressant drug that works by blocking certain receptors in the brain. It helps to relax blood vessels and improve blood flow in the testicles.

Using Imipramine alongside high-quality natural supplements such as Semenax can speed up the process of increasing sperm count. This supplement has been clinically proven to increase semen volume, sperm motility, and overall sperm count.

Side effects of Imipramine may include dry mouth, nausea, and drowsiness. In some cases, it may also cause allergic reactions such as hives or rashes. Additionally, it can cause low blood pressure and heart rate. Remember it’s essential to follow your doctor’s instructions closely and not exceed the recommended dosage when taking Imipramine.


On rare occasions, surgery may be used to increase sperm count. This is usually done if there’s an underlying medical condition that is causing the low sperm count.

Surgery might include:

  • Varicocelectomy: This is a procedure that removes enlarged veins around the testicles and restores normal blood flow to the area. It helps to increase sperm count and quality.
  • Microsurgical Epididymal Sperm Aspiration (MESA): This is a procedure that involves surgically removing sperm from the epididymis and then using it for assisted reproduction techniques, such as IVF (in vitro fertilization).
  • Testicular Biopsy: This is a procedure that involves taking a small sample of tissue from the testicles in order to examine it and identify any underlying causes of low sperm count.
  • Testicular Sperm Extraction (TESE): This procedure involves surgically removing a small piece of tissue from the testicles in order to extract viable sperm, which can then be used for fertility treatments such as IVF or artificial insemination. The success rate of TESE is relatively low, but it can be a good option for those who are unable to produce sperm through other methods.

There are certain conditions that may require more specialized surgery to increase sperm count. These procedures are:

  • Bilateral Vasovasostomy: This is a procedure that reconnects the tubes that allow sperm to travel from the testis and penis.
  • Vasoepididymostomy: This procedure is used when the tubes carrying sperm from the testicles to the penis are blocked. It involves surgically connecting these tubes back together, restoring normal function.
  • Epididymovasostomy: This procedure is used to treat cases of blocked sperm ducts. It involves surgically connecting the epididymis (the tube that carries sperm from the testicles) to the vas deferens (the tube that carries sperm to the penis).

These procedures are more complex and involve more risks than other treatments for increasing sperm count. Therefore, it is important to explore all options available, including taking herbs to increase sperm count or trying to lose weight to increase sperm count alongside prescribed medication.

How to Get the Best from Medication to Increase Sperm Count

Medications to increase sperm count can be an effective way of tackling male fertility issues. However, it’s important to make sure that you are taking the right medication and using it correctly so that you get the best possible results. Here we provide some tips on how to get the most from this type of treatment.

1. Always Consult your Doctor First

It’s vital that you consult with your doctor before taking any medication to increase sperm count. This will ensure that the medication is suitable for you, as it may not be advisable if you have a particular medical condition or if you are already taking other medications. Your doctor will also help you to identify any possible side effects and advise on the best course of action for you.

2. Follow the Dosage Instructions Carefully

When taking medication to increase sperm count, it is extremely important that you follow the dosage instructions given by your doctor carefully. Taking too much or too little of the recommended dose can have a significant impact on its effectiveness and may even be dangerous in some cases.

3. Avoid Alcohol and Tobacco Products

It’s important to avoid drinking alcohol and smoking tobacco products while taking medication to increase sperm count, as these can have a detrimental effect on the effectiveness of the treatment. If you’re unable to completely quit these substances, try to limit their consumption as much as possible.

4. Eat a Balanced Diet

Eating a healthy and balanced diet is essential. A nutritious diet should include plenty of fruits and vegetables, whole grains, lean proteins, nuts, seeds, and almonds to increase sperm count. Eating the right foods can help to support your fertility levels by providing the necessary minerals and vitamins to increase sperm volume.

5. Exercise Regularly

Regular exercise is also important when trying to increase sperm count. Exercising for at least 30 minutes per day can help to boost your fertility levels as it helps to reduce stress, improve circulation and regulate hormones.

Some of the best forms of exercise for increasing sperm count include swimming, running, cycling, and yoga.

6. Get Enough Sleep

One way to enhance the effectiveness of medication to increase sperm count is to get enough sleep. Studies have shown that men who get around seven hours of quality sleep every night are more likely to have higher sperm counts than those who don’t.

To ensure you get enough sleep, try to have a regular bedtime routine and stick to it. Avoid caffeine, alcohol, and late-night meals before bedtime, and spend at least 30 minutes relaxing in the evening before you go to sleep.

7. Try Natural Supplements

There are some natural supplements that can help to increase sperm count, such as zinc, folic acid, selenium, and vitamin C. However, be sure to consult with your doctor before taking any of these supplements, as they may interact with other medications you are already taking.

By following the tips above, you can get the most out of your medication to increase sperm count and significantly improve your chances of becoming a father. Remember that you should always take the medication as prescribed and to make any necessary lifestyle changes in order to maximize its effectiveness.

If you have any questions or concerns about taking medications to increase sperm count, don’t hesitate to speak with your doctor. They will be able to provide further advice and support so that you are able to get the best possible results. For instance, if everything fails and you want to father a child, your doctor can advise you on other fertility options such as surrogacy or adoption. Sperm donation may also be an option.

Good luck!

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About Thomas Arkenis

Avatar photoThomas is a natural health enthusiast and our resident journalist. He's an avid contributor to various traditional medicine conferences and forums, Thomas stays on top of the latest industry trends to bring you the latest product and ingredient innovations.

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